Table 1.
Comparison of pregnancies in the first trimester by mRNA COVID-19 vaccination status.
| Variables * | Total (n = 3094) | Vaccine (n = 927) | No Vaccine (n = 2167) | p-Value |
|---|---|---|---|---|
| Age, years (mean ± SD) | 30.7 ± 6.1 | 29.5 ± 7.3 | 31.6 ± 5.6 | <0.001 t |
| Weight, BMI (mean ± SD) | 23.9 ± 5.4 | 24.1 ± 5.2 | 23.8 ± 5.4 | 0.152 t |
| Previous SARS-CoV-2 infection | 341 (11.0%) | 148 (15.9%) | 193 (8.9%) | <0.001 |
| Nulliparous | 1973 (63.8%) | 584 (62.9%) | 1389 (64.1%) | 0.560 |
| Infertility treatment | 106 (3.4%) | 30 (3.2%) | 76 (3.5%) | 0.704 |
| Spontaneous abortion | 395 (12.8%) | 124 (13.4%) | 271 (12.5%) | 0.506 |
| Abnormal karyotype | 30 (0.9%) | 11 (1.2%) | 19 (0.9%) | 0.420 |
| Pregnancy complications ** | 229 (7.4%) | 64 (6.9%) | 165 (7.6%) | 0.489 |
| Chronic conditions *** | 199 (6.4%) | 63 (6.8%) | 136 (6.3%) | 0.589 |
| Frequent smoking | 394 (12.7%) | 110 (11.9%) | 284 (13.1%) | 0.343 |
* Data reported as n(frequency) unless specified differently; ** Pregnancy complications include: high fever, hyperemesis gravidarum, vaginal bleeding, abdominopelvic pain, ectopic pregnancy, and gestational trophoblastic disease; t—Unpaired Student’s t-test. *** Chronic conditions include pregestational diabetes mellitus, cardiac disease, essential hypertension, respiratory disease, and autoimmune disease.