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. 2022 Mar 4;12(3):393. doi: 10.3390/jpm12030393

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Protein–protein network of DEGs. Blue color node showing upregulated genes and yellow color node showing downregulated genes of non-small cell lung cancer vs. normal. (B) Top-10 hub, and (C) bottleneck genes of PPI network retrieved from significant modules (dark color showing higher value in analysis, all are upregulated except the blue which represents downregulated genes) (D,E) Top-two modules after integrated analysis of PPI network (D) Modules 1 (E) Module 2. Node showing genes, lines denoted interaction between genes.