Table 2.

Building blocks included in the digital models of major dysmood disorder (DMDM).

Building Blocks Of Depression	Description	Examples in the Current Conceptual Analysis
Causome	All causal factors that increase risk toward MDMD (genetic, environmental, and lifestyle factors)	Early lifetime trauma (ELT)
Protectome	All factors that protect against the onset of MDMD (genetic, environmental, and lifestyle factors)	High high-density lipoprotein cholesterol paraoxonase 1 gene (PON1)
Risk-resilience index	Composite based on risk and resilience factors	Early lifetime trauma by PON1 gene interactions
AOP (adverse outcome pathways)	Pathways leading to a medical disease	Latent vectors extracted from neuro-oxidative and neuro-immune biomarkers
Brainome	Aggregate of brain imaging assessments	Changes in the brain connectome
Cognitome	Aggregate of impairments in cognitive functions	Latent vector extracted from executive, attention, and memory dysfunctions
Symptomatome	Aggregate of all symptoms, severity of illness, global clinical impression (CGI)	Latent vector extracted from symptoms, severity indices, GCI, suicidal behaviors
Phenomenome	Self-experience of the illness	Latent vector extracted from phenomenome data including self-rated disabilities and quality of life
Phenome	All symptomatome and phenomenome features	Latent vector extracted from symptomatome and phenomenome data