Table 2.
Building Blocks Of Depression | Description | Examples in the Current Conceptual Analysis |
---|---|---|
Causome | All causal factors that increase risk toward MDMD (genetic, environmental, and lifestyle factors) | Early lifetime trauma (ELT) |
Protectome | All factors that protect against the onset of MDMD (genetic, environmental, and lifestyle factors) | High high-density lipoprotein cholesterol paraoxonase 1 gene (PON1) |
Risk-resilience index | Composite based on risk and resilience factors | Early lifetime trauma by PON1 gene interactions |
AOP (adverse outcome pathways) | Pathways leading to a medical disease | Latent vectors extracted from neuro-oxidative and neuro-immune biomarkers |
Brainome | Aggregate of brain imaging assessments | Changes in the brain connectome |
Cognitome | Aggregate of impairments in cognitive functions | Latent vector extracted from executive, attention, and memory dysfunctions |
Symptomatome | Aggregate of all symptoms, severity of illness, global clinical impression (CGI) | Latent vector extracted from symptoms, severity indices, GCI, suicidal behaviors |
Phenomenome | Self-experience of the illness | Latent vector extracted from phenomenome data including self-rated disabilities and quality of life |
Phenome | All symptomatome and phenomenome features | Latent vector extracted from symptomatome and phenomenome data |