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. 2022 Mar 21;23(6):3387. doi: 10.3390/ijms23063387

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Associations between circulating miRNAs and clinical outcomes of ischemic stroke. Circulating miRNA profiles of stroke BL patients were compared with healthy controls based on the 90-day clinical follow up (mRS scores). Stroke BL patients with good outcome (discovery cohort; n = 77 and validation cohort; n = 84) and poor outcome (discovery cohort; n = 18 and validation cohort; n = 12) were compared with healthy controls (discovery cohort; n = 46 and validation cohort; n = 47). (A) Venn diagram lists the differentially regulated and overlapping circulating miRNAs in healthy controls versus stroke good outcome and stroke poor outcome patients. (B) Box and whiskers plots show the difference in counts per million (CPM) in stroke poor outcome (PO) and healthy controls (HC) in discovery (gray) and validation (light blue) cohorts of the 3 differentially regulated miRNAs, which were unique to stroke poor outcome patients. Mean with minimum and maximum values, and upper and lower quartiles are depicted for each data set with significant comparisons annotated by an asterisk (*) on top (p < 0.0005).