. 2022 Mar 20;13(3):549. doi: 10.3390/genes13030549

Table 3.

Association of demographic and clinicopathological characteristics of the breast cancer cohort.

Variables	Total	HK2		PKM2		PFKM
Variables	Total	Mean ± SEM	p-Value	Mean ± SEM	p-Value	Mean ± SEM	p-Value
Age of disease onset <45	30	1.197 ± 0.1129	0.0423 ^#	2.112 ± 0.4516	0.5593 ^#	2.393 ± 0.2688	0.0038 ^#
Age of disease onset >45	30	1.786 ± 0.3399	0.0423 ^#	1.599 ± 0.2239	0.5593 ^#	4.495 ± 0.6518	0.0038 ^#
Premenopausal status	25	1.011 ± 0.1066	0.0233 ^#	0.9701 ± 0.1295	0.0192 ^#	2.229 ± 0.3476	0.0183 ^#
Postmenopausal status	35	1.912 ± 0.3129	0.0233 ^#	1.741 ± 0.2095	0.0192 ^#	4.073 ± 0.5835	0.0183 ^#
Laterality (left)	30	1.553 ± 0.3226	0.1257 ^#	1.044 ± 0.1162	0.0488 ^#	2.584 ± 0.3395	0.5137 ^#
Laterality (right)	30	1.909 ± 0.3522	0.1257 ^#	2.233 ± 0.4911	0.0488 ^#	3.368 ± 0.5807	0.5137 ^#
Tumor	60	1.948 ± 0.2848	<0.0001 ^¥	1.960 ± 0.09343	<0.0001 ^¥	3.056 ± 0.3269	<0.0001 ^¥
Control	60	1.000 ± 0.1055	<0.0001 ^¥	1.000 ± 0.2483	<0.0001 ^¥	1.000 ± 0.15330	<0.0001 ^¥
Grade I/II	45	1.058 ± 0.05400	0.1121 ^#	1.309 ± 0.1353	0.2237 ^#	1.976 ± 0.2425	0.0403 ^#
Grade III	15	1.314 ± 0.1560	0.1121 ^#	2.165 ± 0.6173	0.2237 ^#	2.987 ± 0.4276	0.0403 ^#
Stage I/II	41	1.496 ± 0.1572	0.0459 ^#	1.161 ± 0.1164	0.0302 ^#	2.786 ± 0.4199	0.0459 ^#
Stage III/IV	19	2.694 ± 0.6708	0.0459 ^#	1.881 ± 0.2609	0.0302 ^#	1.241 ± 0.1621	0.0459 ^#
N0/N1	49	1.595 ± 0.2565	0.0010 ^#	1.582 ± 0.1863	0.0084 ^#	2.123 ± 0.2261	0.0078 ^#
N2/N3	11	3.171 ± 0.5819	0.0010 ^#	3.529 ± 0.8762	0.0084 ^#	4.985 ± 1.071	0.0078 ^#
No metastasis (M0)	57	2.259 ± 0.6133	0.0039 ^#	1.620 ± 0.1726	0.0088 ^#	2.015 ± 0.2073	0.0432 ^#
Distant metastasis (M1)	3	7.009 ± 1.794	0.0039 ^#	4.066 ± 0.6310	0.0088 ^#	4.816 ± 1.835	0.0432 ^#
T Stage: T1/T2	40	1.349 ± 0.1343	0.0499 ^#	1.652 ± 0.2400	0.0090 ^#	1.801 ± 0.2317	0.0026 ^#
T Stage: T3/T4	20	2.299 ± 0.5588	0.0499 ^#	2.480 ± 0.4631	0.0090 ^#	3.205 ± 0.3991	0.0026 ^#

^¥ Wilcoxon signed rank test; ^# Mann–Whitney U test; SEM = standard error mean.