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. 2022 Feb 23;14(3):489. doi: 10.3390/pharmaceutics14030489

Table 1.

Category for ranking recommendations and evidence levels adopted in the guidelines. Referenced from the report [16] developed by this committee, Oxford University Press, 2022.

Category, Grade Definition
I Strong recommendation with strong evidence for efficacy with clinical benefit
II General recommendation with moderate evidence for efficacy with clinical benefit
III-A Suggestion to encourage use by expert opinion without sufficient evidence
III-B Insufficient evidence to make any suggestion
III-C Suggestion to discourage use because of insufficient evidence
IV Recommendation against use with sufficient evidence of no clinical efficacy or increased adverse outcomes