Table 3.
Distribution of AUC at initial TDM in each regimen for patients with normal renal function.
| Regimen | LD | MD (q12h) | No. of Patients |
Median (IQR) of AUC (μg·h/mL) | ||
|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Steady State | ||||
| A-1 | None | 15 mg/kg | 69 | 321.9 * (265.1–396.1) |
390.4 * (326.5–444.6) |
417.9 * (354.5–477.0) |
| A-2 | None | 20 mg/kg | 20 | 355.9 * (303.1–455.7) |
429.8 (378.5–488.8) |
456.1 (420.0–503.3) |
| B-1 | 25 mg/kg | 15 mg/kg | 64 | 410.0 * (352.3–473.5) |
407.0 * (353.0–454.6) |
422.3 ** (351.8–473.8) |
| B-2 | 30 mg/kg | 20 mg/kg | 71 | 472.2 (403.3–543.4) |
459.9 (369.2–530.5) |
472.0 (374.7–556.8) |
AUC: area under the concentration-time curve; TDM: therapeutic drug monitoring; LD: loading dose; MD: maintenance dose; IQR: interquartile range. *: vs. B-2, p < 0.01; **: vs. B-2, p = 0.01.