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. 2022 Feb 25;11(3):293. doi: 10.3390/pathogens11030293

Figure 2.

Figure 2

Crystal structures of the NS2B-NS3 proteases of DENV-2 (A) and DENV-3 (B) in the absence (A) and presence (B) of a substrate analog. (A) The open inactive conformation of the DENV-3 NS2B-NS3 protease in the unbound state (PDB ID of 2FOM). The NS2B cofactor is colored in purple and NS3 protease in yellow. (B) The closed active conformation of the DENV-3 NS2B-NS3 protease in complex with a substrate peptide analog (magenta sticks) (PDB ID of 3U1I). The NS2B cofactor is colored in blue and NS3 protease in orange. The catalytic triad His51-Asp75-Ser135 is displayed in stick representation.