Table 1.
Competitive inhibitors of flavivirus NS2B-NS3 protease.
| Number (Name) of Compound | Targeted Virus | IC50 (or Ki) (μM) | EC50 (μM) | In Vivo | Reference |
|---|---|---|---|---|---|
| 1 (Novobiocin) | ZIKV | 14.2 ± 1.1 | 42.63 | Yes | [61] |
| 2 (Asunaprevir) | ZIKV | 6.0 | 4.7 | [62] | |
| 3 (Simeprevir) | ZIKV | 2.6 | 0.4 | [62] | |
| 4 (Carbazole-based amidines) | ZIKV | 0.52 | 1.25 | [63] | |
| 5 (MK-591) | ZIKV | 3.0 | 3.1 | [64] | |
| 6 (JNJ-40418677) | ZIKV | 3.9 | 3.2 | [64] | |
| 7 (4-CF3-benzyl ether) | TBEV | 0.92 | [65] | ||
| ZIKV | 1.64 | ||||
| 8 | ZIKV | 0.25 | [65] | ||
| TBEV | 0.97 | ||||
| DENV | 0.05 | 3.4 | |||
| WNV | 0.018 | 15.5 | |||
| 9 | ZIKV | 0.94 | [65] | ||
| TBEV | 3.72 | ||||
| 10 (Policresulen) | DENV-2 | 0.81 | 8.47 | [66] | |
| 11 | DENV-2 | 0.95 | [67,68] | ||
| 12 | DENV | 1.1 | 2.0 | [67] | |
| 13 (PCRARIYGGCA) | DENV-3 | Ki = 2.9 | [69] | ||
| 14 (C30H25NO5) | DENV-2 | 17.46 | 14.9 | [70] | |
| 15 (C34H23NO7S2) | DENV-2 | 9.09 | 11.8 | [70] | |
| 16 (Peptide-hybrid inhibitors based on 2,4-thiazolidinedione scaffold) | WNV | 0.75 | [71] | ||
| DENV | 1.05 | ||||
| 17 (α-aminoalkylphosphonates) | DENV-2 | Ki = 0.4 | [72] | ||
| 18 (Theaflavin-3,3′-digallate (ZP10) | ZIKV | 7.65 | 3 | [73] |