Table 2.

Noncompetitive inhibitors of flavivirus NS2B-NS3 protease.

Number (Name) of Compound	Targeted Virus	IC50 (μM)	EC50 (μM)	In Vivo	Reference
19 (Temoporfin)	DENV-2	1.1 ± 0.1	0.020		[75]
	ZIKV		0.024	Yes
	WNV		0.010
	JEV		0.011
	YFV		0.006
20 (Niclosamide)	DENV-2	12.3 ± 0.6	0.55		[75,76]
	ZIKV		0.48
	WNV		0.54
	JEV		1.02
	YFV		0.84
21 (Nitazoxanide)	DENV-2	15.9 ± 0.9			[75,77]
	ZIKV		1.48
	JEV		0.39	Yes
(Tizoxanide)	DENV-2		0.38		[78]
	YFV		0.23
22 (Methylene blue)	DENV-2	8.9	0.36		[79] [79]
	ZIKV		0.087–0.2	Yes
23 (Erythrosin B)	DENV-2	1.9	1.2		[80]
	ZIKV	1.7	0.62	Yes
	WNV		0.66
	JEV		0.35
	YFV		0.57
24 (JMX0902)	ZIKV	2.6	0.3		[81]
25 (JMX0207)	DENV-2	8.2	0.31		[82]
	ZIKV		0.3	Yes
26 (NSC135618)	DENV-2	1.8	0.81		[14]
	ZIKV		1.0
	WNV		1.27
	YFV		0.28
27	ZIKV	21.7			[83]
28	ZIKV	3.1			[83]
29	ZIKV	0.20 ± 0.01	EC68 0.3 or 0.6	Yes	[83,84]
	DENV-2	0.59 ± 0.02
	DENV-3	0.52 ± 0.06
	WNV	0.78 ± 0.02
30	ZIKV	0.13	EC68 0.6		[84]
	DENV-2	2.4
	WNV	0.82
31	DENV-2	2.56 ± 1.03	<30		[85]
32	DENV-2	2.01± 0.98	<30		[85]
33	DENV-2	5.28 ± 1.89	<30		[85]
(R)-34	DENV-2	0.32	<3		[86]
(R)-35	DENV-2	0.51			[86]
(S)-35	DENV-2	0.58			[86]