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The hierarchical organization used to group histopathology terms of similar findings (and mechanism) for hepatotoxicity; findings were extracted from preclinical toxicity study reports for regulatory submissions [145].
| LIVER TOXICITY | |
|---|---|
| General clusters | Specific clusters |
| Tissue damage | Necrosis |
| Degeneration | |
| Inflammatory changes | Inflammation |
| Infiltration | |
| Structural alterations | Proliferation |
| Hyperplasia | |
| Hypertrophy | |
| Accumulative lesions | Steatosis |
| Vacuolation | |
