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Classification of in silico models based on methodology, endpoint, and source of data (adapted from Hewitt and Przybylak [188])
| Methodology: | • Statistical-based • Expert rule-based |
| Endpoint: | • General hepatotoxicity • Specific endpoints • Molecular initiating events (MIEs) |
| Source of data: | • In vitro • In vivo (human) • In vivo (animal) |
