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Influence of shikonin derivatives in chondrocyte viability. (A) Chemical structures of shikonin (S), acetylshikonin (AS), and cyclopropylshikonin (CS); (B) cell growth of healthy chondrocytes (HC) and human primary osteoarthritis chondrocytes (pCH-OA) was inhibited in a dose-dependent manner by shikonin derivatives (mean ± SD, n = 6, measured in biological quadruplicates).
