Table 1.
Mtb antigens used to assess in vitro IFN-γ production for LTBI diagnosis.
| Antigens | Loci Function | In Vitro Assessment |
|---|---|---|
| PPD (purified tuberculin derivative) | Loci not studied; functions are diverse | IFN-γ production and other tests (especially widely used in TST) |
| ESAT-6, early secretory antigen/CFP-10, antigen culture filtrate | RD1 | IFN-γ production and other tests (level of T-lymphocytes producing IFN-γ) |
| Rv1733 | DosR | IFN-γ production |
| Rv1471, Rv2662, Rv3862 | Loci (antigens) of reactivation | IFN-γ production |
| Rv2389 | Rpf locus (antigens), with exit of mycobacteria from dormant state | IFN-γ production |
| Rv2660 | Loci (antigens) metabolism in conditions of reduced nutrient intake | IFN-γ production |
| Rv0244, Rv1909, Rv2913 | Loci (antigens) with stress induced Mtb functions | IFN-γ production |
| Rv0847, Rv0967, Rv1806, Rv2380M, Rv2435n, Rv2642 | Loci (antigens) expressed by Mtb in vivo (IVE) | IFN-γ production |
| α-crystallin (16kDa-R2031c, hspX) | “Latency” | IFN-γ production |
| Rv3407 | “Latency” | IFN-γ production |
| Rv2660, Rv2659 | RD11, locus (antigens) of aging | IFN-γ production |
| PPD, CFP-10, ESAT-6, Rv3879c, Rv3878, Rv3873, α-crystallin | Various, including DosR | IFN-γ production |