Table 3.
Association analysis of rs3742330 polymorphism in DICER1 with pseudoexfoliation glaucoma cases in men and women.
| Group | Genetic Model 1 | Genotype | Control n (%) |
Cases n (%) |
Odds Ratio (95% Confidence Interval) | p-Value 2 | AIC 3 | BIC 4 | p-Value 2,5 |
|---|---|---|---|---|---|---|---|---|---|
| Men | Co-dominant | A/A | 109 (85.2) | 57 (93.4) | 1.00 | 0.190 | 240.4 | 250.1 | 0.430 |
| A/G | 18 (14.1) | 4 (6.6) | 0.42 (0.14–1.32) | ||||||
| G/G | 1 (0.8) | 0 (0.0) | 0.00 (0.00–NA) | ||||||
| Dominant | A/A | 109 (85.2) | 57 (93.4) | 1.00 | 0.087 | 238.8 | 245.3 | 0.280 | |
| A/G-G/G | 19 (14.8) | 4 (6.6) | 0.40 (0.13–1.24) | ||||||
| Recessive | A/A-A/G | 127 (99.2) | 61 (100.0) | 1.00 | 0.380 | 241.0 | 247.4 | 0.380 | |
| G/G | 1 (0.8) | 0 (0.0) | 0.00 (0.00–NA) | ||||||
| Over-dominant | A/A-G/G | 110 (85.9) | 57 (93.4) | 1.00 | 0.120 | 239.3 | 245.7 | 0.350 | |
| A/G | 18 (14.1) | 4 (6.6) | 0.43 (0.14–1.33) | ||||||
| Log-additive | - | - | - | 0.40 (0.13–1.21) | 0.076 | 238.6 | 245.1 | 0.240 | |
| Women | -- | A/A | 95 (84.1) | 31 (93.9) | 1.00 | 0.120 | 157.6 | 163.6 | 0.120 |
| A/G | 18 (15.9) | 2 (6.1) | 0.34 (0.07–1.55) | ||||||
| G/G | 0 (0.0) | 0 (0.0) | - |
1 Tested by SNPStat; 2 chi-square analysis; 3 AIC, Akaike information criterion; 4 BIC, Bayesian information criterion; 5 adjusted for age and sex. Note: No rare homozygous genotype G/G was observed among women.