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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Lancet Neurol. 2022 Feb;21(2):140–152. doi: 10.1016/S1474-4422(21)00375-6

Figure 5: Longitudinal PiB PET:

Figure 5:

Individual pathogenic variant carriers are plotted in panel A, with each point representing a PiB PET measurement and lines connecting observations from the same participant. To examine how amyloid PET signal may vary longitudinally by stage of disease, variant carriers were separated into early asymptomatic, late asymptomatic, and impaired phases of autosomal dominant Alzheimer’s disease, and the yearly change in PiB PET signal was calculated from the available longitudinal data (panel B). P-values shown are FDR corrected.