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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Lancet Neurol. 2022 Feb;21(2):140–152. doi: 10.1016/S1474-4422(21)00375-6

Figure 6: Variant-dependent Variability in Regional Amyloid Burden:

Figure 6:

Trajectories of striatal mean PiB SUVR across EYO with pathogenic variants grouped according to affected protein domain (A) or in PSEN1 carriers with genetic variants before or after codon 200 (B). Individual variant categories from panel A are depicted in panels C-K, with cortical mean shown in colored solid lines and striatal mean in gray dashed lines. + denotes p ≤ 0.05 for main effect of variant grouping relative to other pathogenic variant carriers; † indicates p ≤ 0.0005 for the presence of a codon-based grouping by EYO interaction; * indicates p ≤ 0.05 for comparison of cortical to striatal PiB PET SUVR within each variant grouping. P-values are FDR corrected.