Appendix 2—figure 1. Gene Ontology (GO) analysis of hypomethylated genes in soleus muscles from double heterozygous (dHT) mice treated for 15 weeks with TMP269 + 5-Aza drug vs. vehicle-treated dHT mice.

Genes showing a ≥2.0-fold decrease in methylation (p ≤ 0.05) were analyzed by DAVID functional annotation to produce gene clusters (≥2 genes/cluster) corresponding to 51 GO annotation terms. GO terms corresponding to biological process (GOTERM_BP_FAT and KEGG_PATHWAY) were extracted and are plotted with the numbers of genes (as a percentage of the total) for each term. GO terms with <2% of the total genes were not plotted unless significantly enriched (Benjamini ≤0.05).