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. 2022 Mar 23;14(1):2056291. doi: 10.1080/20002297.2022.2056291

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effect of NAM on the cariogenicity of S. mutans in a rat caries model. (a) and (b) Keyes scores of the rats’ molar teeth on the buccal surface and sulcal surface. Each plot represents the caries score of each rat (n = 7). Error bars denote the standard deviations. E, enamel; Ds, dentin exposed, Dm, ¾ of the dentin affected, Dx, whole dentin affected. (c) Mandibular molars of the model rats, the upper-panel shows the buccal view, the lower-panel shows the sulcal view, and arrows indicate the representative carious lesions. (d) Effects of NAM on the population of S. mutans in rats’ dental plaque. (e) Effects of NAM treatments on rat weight gains. The results were averaged from three separate experiments and are presented as means ± standard deviations. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the untreated control. ns, not statistically significant compared with the untreated control.