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. 2022 Mar 23;29(1):937–949. doi: 10.1080/10717544.2022.2053762

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — ND-DOX-loaded platelets infiltrated in tumor tissue and were activated to discharge Nano-DOX. (A) Graft tumors of Lewis lung cancer cells (LLC) that had received empty platelets or ND-DOX-loaded platelets displayed increased expression of markers of platelets (CD42b, CD41) and platelet activation (CD62p). (B) Ex vivo graft tumors that had received ND-DOX-loaded platelets exhibited pronounced DOX-derived fluorescence. (C) Fluorescent microscopy revealed extensive distribution of DOX-derived fluorescence in the tissue of graft tumors that had received ND-DOX-loaded platelets. Plt@ND-DOX refers to platelets loaded with ND-DOX; Plt@DOX refers to platelets loaded with DOX.