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. 2022 Mar 23;29(1):937–949. doi: 10.1080/10717544.2022.2053762

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — ND-DOX-loaded platelets exhibited high anti-tumor therapeutic potency. (A) Excised graft tumors of graft tumors of Lewis lung cancer cells (LLC). (B) Tumor growth from cancer cell inoculation until animal sacrifice. (C) Tumor growth over a 4-day treatment period from day 15 to day 18. The animals were sacrificed on day 18. (D) Tumor growth rates over the treatment duration (from day 15 to day 18) were calculated by regression analysis. (E) Expression of proliferation markers (PCNA and CDK4) and apoptosis marker BAX in the tumor tissues. Plt@ND-DOX refers to platelets loaded with ND-DOX; Plt@DOX refers to platelets loaded with DOX. Dose normalized to doxorubicin was 0.1 mg/kg bw for Plt@ND-DOX and ND-DOX. Doses for DOX were 0.1 and 5 mg/kg bw. Values were means ± SD (n ≥ 3, * p < .05).