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. 2022 Mar 23;29(1):937–949. doi: 10.1080/10717544.2022.2053762

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — ND-DOX-loaded platelets exhibited no apparent systemic and vital organ toxicity. (A) Animal body weight growth from cancer cell inoculation until animal sacrifice. (B) Animal body weight growth over a 4-day treatment period from day 15 to day 18. The animals were sacrificed on day 18. (C) Body weight growth rates over the treatment duration (from day 15 to day 18) were calculated by regression analysis. (D) HE staining of vital organ tissues. Plt@ND-DOX refers to platelets loaded with ND-DOX; Plt@DOX refers to platelets loaded with DOX. Dose normalized to doxorubicin was 0.1 mg/kg bw for Plt@ND-DOX and ND-DOX. Doses for DOX were 0.1 and 5 mg/kg bw. Values were means ± SD (n ≥ 3, * p < .05).