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Antioxidative effect of H2. H2 can directly neutralize •OH and ONOO−, reduce NO production by inhibiting iNOS expression and eliminating NO-derived ONOO− while suppressing NADPH oxidase and MDA, and decrease ROS in mitochondria, which is the main ROS generation location. In addition, H2 can activate Nrf2, inducing HO-1 expression and enhancing the transcription of CAT, GPX1, and GSH.
