Table 6.

Comparison of various CDL predictors between the 2010 and the 2019 ASGE guidelines with study resulted recommendation and comments

Predictors	2010 ASGE guideline CDL predictor category	2019 ASGE guideline CDL predictor category	Comment based on study result
US with stone	Very strong	High	Highest WaOR of all predictors
Acute cholangitis	Very strong	High	Lower WaOR than US with stone; however, still relatively higher WaOR than other predictors
Tbili > 4 mg/dL	Very strong	Not reported	Equivalent multivariate analysis WaOR as compared to acute cholangitis
Tbili > 4 mg/dL  + CBD > 6 mm	Not reported	High	Insufficient data to comment; suspect higher specificity than either alone
Tbili 1.8–4 mg/dL	Strong	Not reported	Relatively low WaOR, equivalent to moderate predictors reported in 2010 ASGE guideline. However, limited studies
CBD > 6 mm	Strong	Intermediate	High WaOR on univariate analysis, low WaOR on multivariate analysis. Relatively high sensitivity and NPV
ALFT	Moderate	Intermediate	Low WaOR, nonspecific
Age > 55 years	Moderate	Intermediate	Low WaOR, nonspecific
Acute pancreatitis	Moderate	Not reported	WaOR < 1, indicates a negative predictor of CDL

It is presumed that the term “likelihood” reported in the 2010 ASGE guideline and “probability” reported in the 2019 ASGE guideline have analogous meanings and, similarly, that the strength qualifiers (e.g. “very strong”) reported in the 2010 ASGE guideline and probability (e.g. “high”) qualifiers reported in the 2019 ASGE guideline have analogous meanings