Table 2.
Patient characteristics of 104 patients who were measuring bone turnover markers
| Parameter | Metastatic bone tumor | P value | ||
|---|---|---|---|---|
| Negative | Positive | |||
| Number | 83 | 21 | ||
| Median age, year (range) |
66 (40–94) |
71 (45–86) |
0.373 | |
| Gender | male/female | 53/30 | 18/3 | 0.055 |
| Stage | I/II/III/IV/unknown | 42/4/21/14/2 | 0/1/4/16/0 | < 0.0001 |
| Tumor histology clear cell/papillary/chromophobe/unclassified/unknown | 72/0/2/3/6 | 11/3/1/3/3 | 0.0008 | |
| Median values of bone turnover markers, (range) | ||||
| ICTP | (ng/mL) |
4.3 (2.2–15.1) |
7.2 (2.8–38.1) |
< 0.0001 |
| BAP | (μg/L) |
12.3 (3.5–51.8) |
13.5 (7.5–34.4) |
0.252 |
| uNTx | (nmolBCE/mmolCr) |
30.0 (5.7–129.6) |
30.6 (6.9–96.1) |
0.536 |
| sNTx | (nmolBCE/mmolCr) |
15.6 (8.7–30.0) |
16.2 (8.6–35.3) |
0.366 |
| TRACP-5b | (mIU/dL) |
330 (109–898) |
353 (87–977) |
0.606 |
| ALP | (IU/L) |
225 (70–2406) |
262 (162–1010) |
0.015 |
| Ca | (mg/dL) |
9.2 (8.2–14.6) |
9.5 (8.4–12.0) |
0.142 |
| LDH | (IU/L) |
193 (107–532) |
201 (137–542) |
0.175 |
ICTP Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen, BAP bone-specific alkaline phosphatase, uNTx urinary N-telopeptide, sNTx serum, N-telopeptide, TRACP-5b Tartrate-resistant acid phosphatase 5b, ALP alkaline phosphatase, Ca serum calcium, LDH lactate dehydrogenase, P value was calculated by Mann–Whitney U test or χ-square test