Table 1.
Demographics of LHON cohort.
| All patients (N = 44) |
ND4 patients (N = 27) |
ND1 patients (N = 8) |
ND6 patients (N = 9) |
ND4 patients aged ≥ 15 at onset (N = 23) |
|
|---|---|---|---|---|---|
| Age at onset of vision lossa (years) | |||||
| Mean (SD) | 27.9 (18.7) | 30.2 (20.1) | 24.9 (15.8) | 23.6 (17.7) | 34.2 (19.0) |
| Median | 21.5 | 23.0 | 17.5 | 21.0 | 25.0 |
| IQR | 16.0, 32.0 | 16.0, 39.0 | 15.5, 29.0 | 14.0, 24.0 | 19.0, 57.0 |
| Min, Max | 4, 71 | 4, 71 | 14, 61 | 8, 68 | 16, 71 |
| Categories of age at onseta | |||||
| ≤12 years old | 5/44 (11.4%) | 3/27 (11.1%) | 0/8 (0.0%) | 2/9 (22.2%) | NA |
| 13 to 14 years old | 3/44 (6.8%) | 1/27 (3.7%) | 1/8 (12.5%) | 1/9 (11.1%) | NA |
| 15 to 17 years old | 6/44 (13.6%) | 3/27 (11.1%) | 3/8 (37.5%) | 0/9 (0.0%) | 3/23 (13.0%) |
| 18 and older | 30/44 (68.2%) | 20/27 (74.1%) | 4/8 (50.0%) | 6/9 (66.7%) | 20/23 (87.0%) |
| Sex | |||||
| Male | 33/44 (75.0%) | 22/27 (81.5%) | 5/8 (62.5%) | 6/9 (66.7%) | 18/23 (78.3%) |
| Female | 11/44 (25.0%) | 5/27 (18.5%) | 3/8 (37.5%) | 3/9 (33.3%) | 5/23 (21.7%) |
| Ethnicity | |||||
| Caucasian/White | 33/44 (75.0%) | 20/27 (74.1%) | 5/8 (62.5%) | 8/9 (88.9%) | 18/23 (78.3%) |
| Black | 1/44 (2.3%) | 1/27 (3.7%) | 0/8 (0.0%) | 0/9 (0.0%) | 1/23 (4.3%) |
| Asian | 1/44 (2.3%) | 1/27 (3.7%) | 0/8 (0.0%) | 0/9 (0.0%) | 0/23 (0.0%) |
| Unknown | 9/44 (20.4%) | 5/27 (18.5%) | 3/8 (37.5%) | 1/9 (11.1%) | 4/23 (17.4%) |
| Country of origin | |||||
| France | 9/44 (20.5%) | 6/27 (22.2%) | 3/8 (37.5%) | 0/9 (0.0%) | 5/23 (21.7%) |
| Italy | 12/44 (27.3%) | 6/27 (22.2%) | 4/8 (50.0%) | 2/9 (22.2%) | 5/23 (21.7%) |
| Spain | 5/44 (11.4%) | 2/27 (7.4%) | 1/8 (12.5%) | 2/9 (22.2%) | 2/23 (8.7%) |
| United Kingdom | 8/44 (18.2%) | 5/27 (18.5%) | 0/8 (0.0%) | 3/9 (33.3%) | 4/23 (17.4%) |
| United States | 10/44 (22.7%) | 8/27 (29.6%) | 0/8 (0.0%) | 2/9 (22.2%) | 7/23 (30.4%) |
IQR inter-quartile range, NA not applicable, SD standard deviation.
aOnset in first-affected eye.