Table 2.
BCVA data collection in REALITY.
| All patients (N = 44) |
ND4 patients (N = 27) |
ND1 patients (N = 8) |
ND6 patients (N = 9) |
ND4 patients aged ≥ 15 at onset (N = 23) |
|
|---|---|---|---|---|---|
| Time from onset to first visit (months) | |||||
| Mean (SD) | 5.7 (7.3) | 6.9 (7.8) | 3.0 (6.2) | 4.5 (6.2) | 6.8 (7.2) |
| Median | 1.9 | 2.9 | 0.6 | 1.3 | 3.0 |
| IQR | 0.5, 11.2 | 0.8, 14.5 | 0.2, 2.0 | 1.1, 6.0 | 0.8, 14.5 |
| Min, Max | 0.0, 25.7 | 0.0, 25.7 | 0.0, 18.2 | 0.0, 17.8 | 0.0, 20.5 |
| Time period of first visit post-onset | |||||
| ≤1 month | 14/44 (31.8%) | 7/27 (25.9%) | 5/8 (62.5%) | 2/9 (22.2%) | 6/23 (26.1%) |
| >1 to 3 months | 13/44 (29.5%) | 7/27 (25.9%) | 2/8 (25.0%) | 4/9 (44.4%) | 5/23 (21.7%) |
| >3 to 6 months | 4/44 (9.1%) | 3/27 (11.1%) | 0/8 (0.0%) | 1/9 (11.1%) | 3/23 (13.0%) |
| >6 to 12 months | 4/44 (9.1%) | 3/27 (11.1%) | 0/8 (0.0%) | 1/9 (11.1%) | 3/23 (13.0%) |
| >2 months | 9/44 (20.5%) | 7/27 (25.9%) | 1/8 (12.5%) | 1/9 (11.1%) | 6/23 (26.1%) |
| Time from onset to last visit (months) | |||||
| Mean (SD) | 32.5 (24.1) | 36.3 (29.8) | 26.0 (6.0) | 26.7 (8.6) | 36.8 (32.2) |
| Median | 30.3 | 30.4 | 27.3 | 30.3 | 29.3 |
| IQR | 23.3, 34.5 | 25.0, 35.4 | 22.2, 31.1 | 18.7, 35.1 | 24.4, 35.3 |
| Min, Max | 14.1, 178.2 | 15.9, 178.2 | 15.3, 31.4 | 14.1, 36.0 | 15.9, 178.2 |
| Time period of last visit post-onset | |||||
| ≤18 months | 4/44 (9.1%) | 1/27 (3.7%) | 1/8 (12.5%) | 2/9 (22.2%) | 1/23 (4.3%) |
| >18 to 24 months | 8/44 (18.2%) | 4/27 (14.8%) | 2/8 (25.0%) | 2/9 (22.2%) | 4/23 (17.4%) |
| >24 to 30 months | 9/44 (20.5%) | 8/27 (29.6%0 | 1/8 (12.5%) | 0/9 (0.0%) | 7/23 (30.4%) |
| >30 to 36 months | 16/44 (36.4%) | 8/27 (29.6%) | 4/8 (50.0%) | 4/9 (44.4%) | 6/23 (26.1%) |
| >36 months | 7/44 (15.9%) | 6/27 (22.2%) | 0/8 (0.0%) | 1/9 (11.1%) | 5/23 (21.7%) |
| Number of eyes with BCVA data available in time period | |||||
| Up to Year 1 after onset | 59/88 (67.0%) | 35/54 (64.8%) | 10/16 (62.5%) | 14/18 (77.8%) | 31/46 (67.4%) |
| Year 1 to Year 2 after onset | 76/88 (86.4%) | 44/54 (81.5%) | 16/16 (100.0%) | 16/18 (88.9%) | 39/46 (84.8%) |
| Year 2 to Year 3 after onset | 59/88 (67.0%) | 42/54 (77.8%) | 10/16 (62.5%) | 7/18 (38.9%) | 34/46 (73.9%) |
| >Year 3 after onset | 14/88 (15.9%) | 12/54 (22.2%) | 0/16 (0.0%) | 2/18 (11.1%) | 10/46 (21.7%) |
| Number of BCVA visits per patient | |||||
| Mean (SD) | 7.9 (4.9) | 7.2 (3.9) | 8.0 (3.7) | 9.9 (8.0) | 7.3 (4.2) |
| Median | 6.0 | 6.0 | 7.0 | 6.0 | 6.0 |
| IQR | 5.5, 8.0 | 5.0, 8.0 | 6.0, 9.0 | 6.0, 10.0 | 4.0, 8.0 |
| Min, Max | 4, 28 | 4, 22 | 4, 16 | 4, 28 | 4, 22 |
BCVA best-corrected visual acuity, IQR interquartile range, SD standard deviation.
Date of onset of vision loss in the first eye to be affected was used to calculate times from onset for each patient.