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. 2022 Mar 25;13:1624. doi: 10.1038/s41467-022-29304-6

Fig. 6. Serial mutational spectrum and clonal changes in AML patients and their PDX models.

Fig. 6

In each patient, clonal changes in the clinical course and PDX engraftment are shown in the fish plot format. a, b Illustrative cases showing that selectively expanded clones in PDX were consistent with clonality at relapse in patients. c A case in which dominant clones consisting of FLT3-ITD and NPM1 mutations persisted in patients at relapse and PDX at engraftment. d A case in which mouse-specific enrichment that did not evolve in a relapsed patient. e A case showing the expansion of a FLT3 inhibitor-resistant clone in PDX. Source data are provided as a Source Data file.