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. 2022 Mar 25;13:1624. doi: 10.1038/s41467-022-29304-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In each patient, clonal changes in the clinical course and PDX engraftment are shown in the fish plot format. a, b Illustrative cases showing that selectively expanded clones in PDX were consistent with clonality at relapse in patients. c A case in which dominant clones consisting of FLT3-ITD and NPM1 mutations persisted in patients at relapse and PDX at engraftment. d A case in which mouse-specific enrichment that did not evolve in a relapsed patient. e A case showing the expansion of a FLT3 inhibitor-resistant clone in PDX. Source data are provided as a Source Data file.