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. 2022 Mar 25;12:5164. doi: 10.1038/s41598-022-09048-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The inferred growth rate over time for KCL-22 cells. The error–bars show the standard deviation, and are inflated somewhat by a degree of multicolinearity between the initial and final growth rates. (A) The growth rate over time in cells exposed to drug rotations, aligned in time by the drug exposure. (B) The growth rate in cells exposed to monodrug therapy (washed every six days but not subject to drug rotation).