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. 2022 Mar 25;12:5211. doi: 10.1038/s41598-022-08561-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell–cell communication networks between cardiac fibroblast and cardiomyocyte subtypes in normal control and HCM conditions. (A) Overall communication network between cardiomyocytes and fibroblasts. Line color indicates ligand broadcast by the cell population with the same color. Lines connect to cell types which expressed cognate receptors. Line thickness is proportional to the number of uniquely expressed ligand-receptor pairs. Loops indicates communication within a cell type. (B,C) Cell–cell communication networks broken down by fibroblast cluster and cardiomyocyte cluster in normal control (B) and HCM (C) conditions. Numbers indicate the quantity of uniquely expressed ligand-receptor pairs between the broadcasting cell type (expressing ligand) and receiving cell type (expressing receptor).