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. 2022 Mar 25;12:5176. doi: 10.1038/s41598-022-08987-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LYVE-1⁺ macrophages colonized in the dental papilla during embryonic tooth development. (A) Immunoperoxidase staining of LYVE-1 at embryonic days (E) 12, 15, and 18 in mouse embryo sections. Arrows: LYVE-1⁺ macrophages. (B) Double immunofluorescence staining of LYVE-1 (green) and pan-macrophage marker CD68 (red) at E18 in mouse embryo sections. (1) and (2) show high magnification of LYVE-1⁺CD68⁺ macrophages and LYVE-1⁻CD68⁺ macrophages, respectively. (C) Double immunofluorescence staining of LYVE-1 (green) and M2 macrophage marker CD163 (red) at E18 in mouse embryo sections. (1) and (2) show high magnification of LYVE-1⁺CD163⁺ macrophages and LYVE-1⁻CD68⁺ macrophages, respectively. (D) Double immunofluorescence staining of LYVE-1 (green) and antigen-presenting cell marker MHC-II (red) at E18 in mouse embryo sections. (1) and (2) show high magnification of LYVE-1⁺MHC⁻ macrophages and LYVE-1⁻CDMHC⁺ macrophages, respectively. Images are representative of at least 3–4 different samples for each condition examined. De dental epithelium, dm dental mesenchyme, eo enamel organ, od odontoblast layer, dp dental papilla. Scale bar 100 µm.