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. 2022 Mar 25;13:1617. doi: 10.1038/s41467-022-29202-x

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Diagram depicting the workflow for the high-throughput specificity profiling assay. b Heatmaps corresponding to the specificity profiles of the indicated ribose inosine-modified crRNAs. The positions of inosine bases are indicated by black arrows. Specificity scores of 1.0 (dark blue) correspond to 100% enrichment for, while scores of −1.0 (dark red) correspond to 100% enrichment against a base-pair at a specific position. Black boxes denote the intended target nucleotide.