Table 2.
Incidence of CVA across various time intervals before and after the index date of RAO.
| All RAO | CRAO | BRAO | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVA (N) | IRR (95% CI) | p | CVA (N) | IRR (95% CI) | p | CVA (N) | IRR (95% CI) | p | ||
| 30-Day comparisons | ||||||||||
| 1st month (days 1–30) post-index date vs. | −6 month | 19 | 3.37 (2.02–5.62) | <0.001 | 6 | 6.33 (2.68–14.98) | <0.001 | 13 | 2.00 (1.03–3.89) | 0.041 |
| −5 month | 24 | 2.68 (1.67–4.26) | <0.001 | 12 | 3.17 (1.66–6.06) | <0.001 | 12 | 2.17 (1.09–4.29) | 0.027 | |
| −4 month | 28 | 2.29 (1.47–3.56) | <0.001 | 12 | 3.17 (1.66–6.06) | <0.001 | 16 | 1.63 (0.87–3.03) | 0.127 | |
| −3 month | 38 | 1.68 (1.13–2.52) | 0.011 | 19 | 2.00 (1.15–3.47) | 0.014 | 19 | 1.37 (0.76–2.47) | 0.299 | |
| −2 month | 48 | 1.33 (0.92–1.94) | 0.132 | 19 | 2.00 (1.15–3.47) | 0.014 | 29 | 0.90 (0.53–1.52) | 0.686 | |
| −1 month | 72 | 0.89 (0.64–1.25) | 0.493 | 34 | 1.12 (0.70–1.78) | 0.638 | 38 | 0.68 (0.42–1.13) | 0.136 | |
| 1–30 days | 64 | REF | 38 | REF | 26 | REF | ||||
| 2 month | 29 | 2.21 (1.42–3.42) | <0.001 | 13 | 2.92 (1.56–5.49) | <0.001 | 16 | 1.63 (0.87–3.03) | 0.127 | |
| 3 month | 22 | 2.91 (1.79–4.72) | <0.001 | 11 | 3.46 (1.77–6.76) | <0.001 | 11 | 2.36 (1.17–4.78) | 0.017 | |
| 4 month | 10 | 6.40 (3.29–12.46) | <0.001 | 2 | 19.00 (4.58–78.76) | <0.001 | 8 | 3.25 (1.47–7.18) | 0.004 | |
| 5 month | 25 | 2.56 (1.61–4.06) | <0.001 | 13 | 2.92 (1.56–5.49) | <0.001 | 12 | 2.17 (1.09–4.29) | 0.027 | |
| 6 month | 15 | 4.27 (2.43–7.49) | <0.001 | 8 | 4.75 (2.22–10.18) | <0.001 | 7 | 3.71 (1.61–8.56) | 0.002 | |
| 7-Day comparisons | ||||||||||
| 1st week (days 1–7) post-index date vs. | −22 week | 3 | 9.67 (2.95–31.73) | <0.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 1 | 13.00 (1.70–99.38) | 0.013 |
| −19 week | 8 | 3.63 (1.66–7.93) | 0.001 | 5 | 3.20 (1.17–8.74) | 0.023 | 3 | 4.33 (1.24–15.21) | 0.022 | |
| −16 week | 5 | 5.80 (2.25–14.98) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 2 | 6.50 (1.47–28.80) | 0.014 | |
| −13 week | 9 | 3.22 (1.52–6.81) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 6 | 2.17 (0.82–5.70) | 0.117 | |
| −10 week | 10 | 2.90 (1.41–5.95) | 0.004 | 4 | 4.00 (1.34–11.97) | 0.013 | 6 | 2.17 (0.82–5.70) | 0.117 | |
| −9 week | 12 | 2.42 (1.23–4.74) | 0.01 | 5 | 3.20 (1.17–8.74) | 0.023 | 7 | 1.86 (0.74–4.66) | 0.187 | |
| −8 week | 7 | 4.14 (1.82–9.46) | <0.001 | 1 | 16.00 (2.12–120.65) | 0.007 | 6 | 2.17 (0.82–5.70) | 0.117 | |
| −7 week | 4 | 7.25 (2.55–20.62) | <0.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 2 | 6.50 (1.47–28.80) | 0.014 | |
| −6 week | 21 | 1.38 (0.79 – 2.42) | 0.260 | 10 | 1.60 (0.73–3.53) | 0.0.244 | 11 | 1.18 (0.53–2.64) | 0.683 | |
| −5 week | 9 | 3.22 (1.52–6.81) | 0.002 | 3 | 5.33 (1.56–18.30) | 0.008 | 6 | 2.17 (0.82–5.70) | 0.117 | |
| −4 week | 6 | 4.83 (2.01–11.64) | <0.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| −3 week | 15 | 1.93 (1.04–3.61) | 0.038 | 4 | 4.00 (1.34–11.97) | 0.013 | 11 | 1.18 (0.53–2.64) | 0.683 | |
| −2 week | 19 | 1.53 (0.86–2.72) | 0.152 | 9 | 1.78 (0.79–4.02) | 0.167 | 10 | 1.30 (0.57–2.97) | 0.533 | |
| −1 week | 31 | 0.94 (0.56–1.55) | 0.796 | 19 | 0.84 (0.43–1.64) | 0.613 | 12 | 1.08 (0.49–2.37) | 0.842 | |
| 1–7 days | 29 | REF | 16 | REF | 13 | REF | ||||
| 2 week | 14 | 2.07 (1.10–3.92) | 0.025 | 8 | 2.00 (0.86–4.67) | 0.109 | 6 | 2.17 (0.82–5.70) | 0.117 | |
| 3 week | 12 | 2.42 (1.23–4.73) | 0.01 | 8 | 2.00 (0.86–4.67) | 0.109 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| 4 week | 7 | 4.14 (1.82–9.46) | <0.001 | 5 | 3.20 (1.17–8.74) | 0.023 | 2 | 6.50 (1.47–28.80) | 0.014 | |
| 5 week | 7 | 4.14 (1.82–9.46) | <.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 5 | 2.60 (0.93–7.29) | 0.069 | |
| 6 week | 9 | 3.22 (1.52–6.81) | 0.002 | 7 | 2.29 (0.94–5.56) | 0.068 | 2 | 6.50 (1.47–28.80) | 0.014 | |
| 7 week | 6 | 4.83 (2.01–11.64) | <0.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| 8 week | 7 | 4.14 (1.82–9.46) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| 9 week | 5 | 5.80 (2.25–14.98) | <0.001 | 1 | 16.00 (2.12–120.65) | 0.007 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| 10 week | 6 | 4.83 (2.01–11.64) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 3 | 4.33 (1.24–15.21) | 0.022 | |
| 13 week | 7 | 4.14 (1.82–9.46) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 4 | 3.25 (1.06–9.97) | 0.039 | |
| 16 week | 1 | 29.0 (3.95–212.90) | <0.001 | 1 | 16.00 (2.12–120.65) | 0.007 | 0 | – | – | |
| 19 week | 5 | 5.80 (2.25–14.98) | <0.001 | 2 | 8.00 (1.84–34.80) | 0.006 | 3 | 4.33 (1.24–15.21) | 0.022 | |
| 22 week | 6 | 4.83 (2.01–11.64) | <0.001 | 3 | 5.33 (1.56–18.30) | 0.008 | 3 | 4.33 (1.24–15.21) | 0.022 | |