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. 2022 Mar 25;12:5196. doi: 10.1038/s41598-022-09074-3

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ndufs2 hemizygosity alters gene expression in immune cell populations. (a) Serum IL-6 measurement in 24 month-old mice. n = 4, unpaired t-test p = 0.8919. (b) Serum TNFa measurement in 24 month-old mice. n = 4, unpaired t-test p = 0.9616. (c) Leukocyte percentage of circulating neutrophils in 27-month-old mice. n = 4, unpaired t-test p = 0.8313. (d) Leukocyte percentage of circulating monocytes in 27-month-old mice. n = 4, unpaired t-test p = 0.6048. (e) Lymphocytic choriomeningitis virus (LCMV) infection response at 20 months of age. Percentage of GP33 responsive CD8 T cells at day 0 and day 7. n = 4, unpaired t-test p = 0.9204. (f) Regulatory T cell GSEA. Demethylation gene set is the top gene ontology biological process gene set enriched in Ndufs2 ^+/- compared to Ndufs2 ^+/+ at 20 months of age. (g, h) Regulatory T cells differential gene expression analysis in 20-month-old mice. (g) Volcano plot individual gene FDR cutoff 0.05, n = 4 (h) GSEA significant MSigDB hallmark gene sets with FDR cutoff of 0.25, n = 4. (i, j) Alveolar macrophage differential gene expression analysis. (i) Volcano plot individual gene FDR cutoff 0.05, n = 4. (j) GSEA significant MSigDB hallmark gene sets with FDR cutoff of 0.25, n = 4. (k, l) CD4 cell differential gene expression analysis in 20-month-old mice. (k) Volcano plot individual gene FDR cutoff 0.05, n = 4 (l) Gene Set Enrichment Analysis (GSEA) Molecular Signatures Database (MSigDB) hallmark gene sets. Significant gene sets with FDR cutoff of 0.25, n = 4. (m, n) CD8 cell differential gene expression analysis in 20-month-old mice. (m) Volcano plot individual gene FDR cutoff 0.05, n = 4. (n) GSEA significant MSigDB hallmark gene sets with FDR cutoff of 0.25, n = 4.