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. 2022 Mar 25;13(3):270. doi: 10.1038/s41419-022-04728-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — In brief, the upregulation of RBM47 inhibits PTC cell proliferation and active autophagy by binding to SNHG5. SNHG5 can recruited USP21, which interacts with FOXO3 to inhibit its ubiquitination and further promote its nuclear translocation. FOXO3 activates autophagy by promoting ATG3 and ATG5 transcription and activates RBM47 transcription to form a positive feedback loop.