Table 4.

Treatment outcomes from ART cycles by cancer history, MA 2004–2013, among cycle starts and among embryos transferred (excluding embryo banking and gestational carrier cycles)

	No cancer (n = 87,973)		History of cancer (n = 1,032)		Crude risk ratio		Multivariable adjusted2 risk ratio
	N	%	N	%	RR1	95% CI	RR1	95% CI
Implantation rate
Among embryo transfers
Range	0–3		0–1.5
Mean (SD)	0.26 (0.38)		0.22 (0.34)		0.81	0.71–0.91	0.89	0.79–1.01
Treatment outcomes
Among all cycle starts
Biochemical	6,313	7.2	66	6.4	0.88	0.69–1.13	0.87	0.68–1.11
CIG	30,755	35.0	277	26.8	0.75	0.68–0.83	0.78	0.71–0.87
Autologous cycles
Biochemical	5,805	7.1	56	6.1	0.85	0.65–1.12	0.84	0.64–1.11
CIG	27,743	34.0	220	24.1	0.69	0.61–0.78	0.73	0.65–0.83
Donor cycles
Biochemical	508	7.9	< 11	-	-	-	-	-
CIG	3,012	46.6	57	47.5	1.01	0.85–1.20	1.01	0.85–1.20
Among embryo transfers
Biochemical	6,302	8.4	66	8.7	1.03	0.82–1.31	1.02	0.81–1.29
CIG	30,723	40.9	277	36.6	0.89	0.81–0.99	0.94	0.85–1.04
Autologous cycles
Biochemical	5,796	8.4	56	8.7	1.03	0.79–1.34	1.02	0.78–1.32
CIG	27,714	40.1	220	34.1	0.85	0.76–0.95	0.92	0.82–1.03
Donor cycles
Biochemical	506	8.6	< 11	-	-	-	-	-
CIG	3,009	50.9	57	51.4	0.99	0.84–1.17	0.99	0.84–1.17
Pregnancy outcomes (restricted to clinical pregnancy)
Live birth	24,815	80.7	214	77.3	0.95	0.89–1.02	0.99	0.93–1.05
Pregnancy loss	5,678	18.5	62	22.4	1.24	0.98–1.57	1.11	0.88–1.39
Autologous cycles
Live birth	22,264	80.3	173	78.6	0.98	0.91–1.05	1.02	0.96–1.08
Pregnancy loss	5,233	18.9	46	20.9	1.12	0.86–1.47	0.98	0.76–1.26
Donor cycles
Live birth	2,551	84.7	41	71.9	0.84	0.71–1.01	0.84	0.71–1.01
Pregnancy loss	445	14.8	16	28.1	1.96	1.23–3.11	1.99	1.26–3.16

¹General estimating equations with a binominal distribution, log link, exchangeable correlation structure were used to estimate relative risks and 95% confidence intervals. Poisson distribution was specified for testing on the implantation rates

²Models were adjusted for maternal age (18–29, 30–34, 35–40, 40 +) and year of cycle started (2004–2007, 2008–2010, 2011–2013)