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Study Design and Flowchart The BioMe Biobank (A) was used for training and the UK Biobank (B) was used for external validation. Statin indicates cholesterol-lowering medications. AUROC = area under the receiver-operating characteristic curve; GBT = gradient boosted trees; NRI = net reclassification improvement; PCE = pooled cohort equations; RF = random forest; SVM = support vector machines.
