. 2022 Feb 25;34:37–41. doi: 10.1016/j.ctro.2022.02.010

Table 3.

Significant associations between tumor histology and endocrine outcomes.

	Univariable		Multivariable^a
Endocrinopathy	Other vs Medulloblastoma OR (95% CI)	p-value	Other vs Medulloblastoma OR (95% CI)	p-value
Hypothyroidism	0.25 (0.10, 0.59)	0.002*	0.26 (0.09, 0.66)	0.005*
Growth Hormone Deficiency	0.14 (0.05, 0.33)	<0.001*	0.20 (0.07, 0.54)	0.002*
Hormone Replacement Therapy	0.13 (0.05, 0.30)	<0.001*	0.18 (0.07, 0.44)	<0.001*

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Abbreviations: XRT, photon radiotherapy; PRT, proton radiotherapy; OR: odds ratio

^a Time adjusted multivariable model including radiation modality and covariates significant on univariable analysis (Endocrinopathy ∼ Radiation modality + time + covariates)

^b Other tumor histology: 11 glioma, 5 ATRT, 3 pineoblastoma, 2 NF-2, 1 chordoma, 1 hemangioendothelioma, 1 meningioma, 1 neurocytoma, 1 PNET

* P < 0.05 and remained significant after false discovery rate correction