Fig. 1.

Nextcast is a software suite whose core functionalities allow robust modelling and analysis of bioinformatics (dark blue) and cheminformatics (dark yellow) data as well as read-across analyses (orange). Nextcast components (outer layer in gray) implement methods for omics data analytic such as preprocessing (eUTOPIA), functional annotation (FunMappOne), dose–response (BMDx, TinderMIX), and co-expression network generation and analysis (INfORM, VOLTA). Advanced modelling algorithms are also available (dark green) including data set simulator (MOSIM), multi-view (MV) clustering (MVDA), and feature selection strategies (FPRF, GARBO). Nextcast also includes methods for quantitative structure–activity relationship (QSAR) such as MaNGA and hyQSAR.