Table 1.

Nextcast components currently utilised and reviewed in the literature.

Tool	Used in	Cited in	Category
eUTOPIA [14]			Bioinformatics
https://github.com/Greco-Lab/eUTOPIA	[24], [25], [5], [26], [27], [28], [29], [30]	[31], [2], [3]	Analytics
R, Shiny			Preprocessing
INfORM [16]			Bioinformatics
https://github.com/Greco-Lab/INfORM	[32], [33], [28], [26], [34]	[31], [2], [3], [4], [35]	Analytics
R, Shiny			Network Analysis
VOLTA [36]			Bioinformatics
https://github.com/fhaive/VOLTA -	-	Analytics
Python			Network Analysis
BMDx [10]			Bioinformatics
https://github.com/Greco-Lab/BMDx			Analytics
R, Shiny	-	[4]	Dose-Responsive
TinderMIX [12]			Bioinformatics
https://github.com/grecolab/TinderMIX			Analytics
R	[5], [23]	[4]	Dose-Responsive
FunMappOne [15]			Bioinformatics
https://github.com/Greco-Lab/FunMappOne	[37], [32], [10], [12], [28],[38], [7], [5], [39],[40], [41], [27], [42]		Analytics
R, Shiny		[3], [43]	Functional Annotation
MOSIM [18]			Bioinformatics
https://doi.org/10.1186/s12859-015-0577-1	-	[44], [4]	modelling Simulator
R
MVDA [17]		[47], [48], [49], [44],[50], [51], [52], [53]	Bioinformatics
https://github.com/Greco-Lab/MVDA_package			modelling
R	[45], [46]	[4], [54], [55], [56]	Multi-view clustering
FPRF [19]			Bioinformatics
https://doi.org/10.1371/journal.pone.0107801.s004		[57], [58]	modelling
R	[59], [60], [50], [61]	[62], [31], [4]	Feature Selection
GARBO [20]			Bioinformatics
https://github.com/Greco-Lab/GARBO			modelling
Python	[63]	[4]	Feature Selection
INSIdE NANO [6]
http://inano.biobyte.de/	[64], [65]	[4], [31], [33]	Read-Across
MaNGA [21]
https://github.com/Greco-Lab/MaNGA
Python	–	[4], [31], [66]	QSAR
hyQSAR [22]	–	[4], [31]	QSAR