Table 3.
Comparison of stimulation index values in CBA/J and BALB/c mice.
| No. | Test chemical | CBA/J |
BALB/c |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose (%) | Mean SI |
+ /- sensitizer | Dose (%) | Mean SI |
+ /- sensitizer | ||||||||||
| VC | L | M | H | PC | VC | L | M | H | PC | ||||||
| 1 | 5-Chloro-2-methyl-4-isothiazolin-one/ 2-methyl-4-isothiazolin-3-one | 2.5, 5, 10 | 1.00 ± 0.69 | 1.87 ± 0.58 | 3.79 ± 1.33 | 4.85 ± 2.39 | 3.48 ± 1.16 | + | 2.5, 5, 10 | 1.00 ± 0.14 | 1.42 ± 0.46 | 2.30 ± 0.65 | 2.81 ± 0.35 | 2.93 ± 0.27 | + |
| 2 | 2,4-dinitrochlorobenzene | 0.05, 0.1, 0.5 | 1.00 ± 0.29 | 1.01 ± 0.18 | 1.59 ± 0.16 | 4.00 ± 0.44 | 2.65 ± 1.09 | + | 0.05, 0.1, 0.5 | 1.00 ± 0.33 | 1.62 ± 0.38 | 1.77 ± 0.47 | 3.44 ± 0.86 | 2.54 ± 0.42 | + |
| 3 | p-Phenylenediamine | 0.5, 1.0, 2.5 | 1.00 ± 0.13 | 1.67 ± 0.06 | 2.15 ± 0.10 | 2.35 ± 0.11 | 3.08 ± 1.25 | + | 0.5, 1.0, 2.5 | 1.00 ± 0.19 | 1.30 ± 0.36 | 1.93 ± 0.81 | 4.20 ± 0.82 | 3.65 ± 1.52 | + |
| 4 | Cobalt (II) chloride | 0.25, 0.5, 1.0 | 1.00 ± 0.62 | 2.64 ± 1.44 | 6.51 ± 1.80 | 5.81 ± 1.15 | 6.76 ± 1.07 | + | 0.25, 0.5, 1.0 | 1.00 ± 0.12 | 1.32 ± 0.07 | 1.40 ± 0.18 | 2.04 ± 0.25 | 2.03 ± 0.10 | + |
| 5 | Isoeugenol | 5, 10, 25 | 1.00 ± 0.12 | 3.23 ± 0.64 | 4.09 ± 0.94 | 4.65 ± 0.69 | 2.99 ± 0.80 | + | 5, 10, 25 | 1.00 ± 0.38 | 1.81 ± 0.33 | 1.59 ± 0.30 | 2.57 ± 0.31 | 1.70 ± 0.58 | + |
| 6 | 2-Mercaptobenzothiazole | 5, 10, 25 | 1.00 ± 0.15 | 1.18 ± 0.17 | 1.43 ± 0.08 | 1.53 ± 0.25 | 3.46 ± 0.89 | – | 5, 10, 25 | 1.00 ± 0.80 | 1.06 ± 0.32 | 1.81 ± 0.81 | 1.98 ± 1.00 | 5.95 ± 0.61 | + |
| 7 | Citral | 10, 25, 50 | 1.00 ± 0.33 | 2.04 ± 0.70 | 2.33 ± 0.52 | 3.05 ± 0.30 | 3.47 ± 0.81 | + | 10, 25, 50 | 1.00 ± 0.32 | 1.29 ± 0.33 | 2.14 ± 0.24 | 3.41 ± 0.45 | 4.39 ± 0.68 | + |
| 8 | α-hexylcinnamaldehyde | 5, 10, 25 | 1.00 ± 0.26 | 1.03 ± 0.06 | 1.28 ± 0.19 | 1.83 ± 0.27 | 2.45 ± 0.42 | + | 5, 10, 25 | 1.00 ± 0.17 | 1.20 ± 0.12 | 1.35 ± 0.13 | 1.97 ± 0.43 | 2.46 ± 0.13 | + |
| 9 | Eugenol | 5, 10, 25 | 1.00 ± 0.33 | 0.95 ± 0.11 | 1.18 ± 0.37 | 1.76 ± 0.04 | 4.94 ± 1.61 | + | 5, 10, 25 | 1.00 ± 0.27 | 1.17 ± 0.21 | 1.64 ± 0.41 | 2.97 ± 0.17 | 2.45 ± 0.95 | + |
| 10 | Phenyl benzoate | 10, 25, 50 | 1.00 ± 0.29 | 1.26 ± 0.21 | 1.40 ± 0.16 | 1.72 ± 0.43 | 3.86 ± 1.01 | + | 10, 25, 50 | 1.00 ± 0.94 | 1.10 ± 0.50 | 1.14 ± 0.37 | 1.84 ± 0.60 | 3.42 ± 0.90 | + |
| 11 | Cinnamyl alcohol | 10, 25, 50 | 1.00 ± 0.34 | 1.25 ± 0.52 | 1.88 ± 0.57 | 2.44 ± 0.21 | 2.72 ± 0.43 | + | 10, 25, 50 | 1.00 ± 0.17 | 1.10 ± 0.31 | 1.94 ± 0.50 | 2.58 ± 0.54 | 3.85 ± 0.62 | + |
| 12 | Imidazolidinyl urea | 10, 25, 50 | 1.00 ± 0.23 | 1.27 ± 0.23 | 1.49 ± 0.16 | 1.71 ± 0.34 | 2.76 ± 0.74 | + | 10, 25, 50 | 1.00 ± 0.22 | 1.42 ± 0.18 | 1.29 ± 0.24 | 2.02 ± 0.24 | 2.03 ± 0.23 | + |
| 13 | Methyl methacrylate | 25, 50, 100 | 1.00 ± 0.09 | 1.15 ± 0.17 | 0.80 ± 0.34 | 0.86 ± 0.15 | 1.71 ± 0.36 | – | 25, 50, 100 | 1.00 ± 0.29 | 1.06 ± 0.20 | 1.12 ± 0.25 | 1.28 ± 0.26 | 3.76 ± 0.63 | – |
| 14 | Chlorobenzene | 10, 25, 50 | 1.00 ± 0.57 | 1.17 ± 0.48 | 1.59 ± 0.62 | 1.37 ± 0.57 | 3.11 ± 0.87 | – | 10, 25, 50 | 1.00 ± 0.85 | 2.40 ± 0.89 | 2.53 ± 0.51 | 3.42 ± 1.02 | 5.88 ± 1.49 | + |
| 15 | Isopropanol | 25, 50, 100 | 1.00 ± 0.20 | 0.88 ± 0.20 | 1.36 ± 0.18 | 1.30 ± 0.17 | 2.66 ± 0.67 | – | 25, 50, 100 | 1.00 ± 0.11 | 1.00 ± 0.21 | 0.86 ± 0.20 | 1.00 ± 0.32 | 2.11 ± 0.63 | – |
| 16 | Lactic acid | 5, 10, 25 | 1.00 ± 0.34 | 0.83 ± 0.39 | 0.86 ± 0.57 | 1.05 ± 0.50 | 2.89 ± 0.43 | – | 5, 10, 25 | 1.00 ± 0.13 | 1.30 ± 0.34 | 0.78 ± 0.08 | 0.84 ± 0.21 | 2.11 ± 0.67 | – |
| 17 | Methyl salicylate | 10, 25, 50 | 1.00 ± 0.27 | 1.35 ± 0.34 | 1.34 ± 0.49 | 1.89 ± 0.37 | 2.74 ± 0.89 | + | 10, 25, 50 | 1.00 ± 0.69 | 2.08 ± 0.72 | 2.52 ± 0.60 | 2.57 ± 1.52 | 3.43 ± 1.70 | + |
| 18 | Salicylic acid | 5, 10, 25 | 1.00 ± 0.15 | 1.29 ± 0.16 | 1.48 ± 0.58 | 1.70 ± 0.30 | 2.58 ± 0.59 | + | 5, 10, 25 | 1.00 ± 0.16 | 0.95 ± 0.16 | 1.19 ± 0.33 | 1.20 ± 0.38 | 2.510.10 | – |
VC, Vehicle control; L, Low dose; M, Medium dose; H, High dose; PC, Positive Control