Fig. 2.

Substrate binding to the Dehydrogenase Domain (DH) of the NADPH Oxidases. A) human NOX2 NADPH Binding Lobe (NBL) of the DH Domain (PDB ID 3A1F). B) csNOX5 DH domain containing FAD Binding Lobe (FBL) with bound FAD (green) and C-terminal mutant PWLELAAA (red) (PDB ID 5O0X). C) DH domain from human DUOX1 full-length structure with bound NADPH and FAD (green) (PDB ID 7D3E). D) Zoom in of FAD binding side of B). E) Zoom in of FAD and NADPH binding site of C). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)