Table 1.

Summary of deposited structures of NOX Family enzymes.

NOX Enzyme	Organism	PDB	Overall High resolution (Å)	Domains	Method	Notes	Citation
NOX2	Homo sapiens	3A1F	2.00	DH (NBL only)	X-ray crystallography	–	–
NOX5	Cylindrospermum stagnale	5O0X	2.20	DH	X-ray crystallography	C-terminal Mutant binds to the NADPH binding side	[12]
NOX5	Cylindrospermum stagnale	5O0T	2.05	TM	X-ray crystallography	–	[12]
NOX5-Calmodulin		6SZ5	2.23	–	X-ray crystallography		[16]
DUOX1-DUOXA1	Mus musculus	6WXU	2.70	TM, PHD	Cryo-EM	dimer-of-dimer inactive form	[13]
DUOX1	Mus musculus	6WXR	3.20	TM PHD DH	Cryo-EM	dimer no NADPH	[13]
DUOX1	Mus musculus	6WXV	3.30	TM PHD DH (NADPH diff)	Cryo-EM	dimer with bound NADPH active form	[13]
DUOX1	Homo sapiens	7D3E	2.80	TM PHD DH PHLD EF	Cryo-EM	Dimer-of-dimer low-calcium inactive form	[14]
DUOX1	Homo sapiens	7D3F	2.60	TM PHD DH PHLD EF	Cryo-EM	Dimer-of-dimer high-calcium active form	[14]