Figure 5.

Comparison of interaction interphase between WNV-Fab and WNV/DENV-scFv chimeric complex.A, WNV_RBS-Fab; B, DENV_RBS-scFv. (Individual contacting residues are listed in Tables S2 and S3). In the RBS, the epitopic residues that contact the complementarity determining regions (CDRs) are located in fusion and bc loop. Fusion and bc loop residues are colored in orange and yellow, respectively. VH-CDR1, VH-CDR2, VH-CDR3, VL-CDR2, and VL-CDR3 are painted pink, green, cyan, brawn, and red, respectively. Receptor-binding surface area and PBSA are painted blue and lime color, respectively. PBS, sparatope-binding surface area; RBS, receptor-binding site; scFv, single chain variable fragment antibody.