Table 7.
Articles of circRNAs that have been mainly investigated.
| First author, year | circRNA | host gene | title | topic | Ref. |
|---|---|---|---|---|---|
| Memczak S, 2013 | CDR1as | CDR1 | Circular RNAs are a large class of animal RNAs with regulatory potency | miRNA sponge | [3] |
| Guo J, 2014 | CDR1as | CDR1 | Expanded identification and characterization of mammalian circular RNAs | properties of circRNAs | [32] |
| Piwecka M, 2017 | CDR1as | CDR1 | Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function | brain function | [33] |
| Xu H, 2015 | CDR1as | CDR1 | The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells | insulin transcription and secretion | [34] |
| Kleaveland B, 2018 | CDR1as | CDR1 | A network of noncoding regulatory RNAs acts in the mammalian brain | mammalian brain | [35] |
| Du W, 2016 | circFOXO3 | FOXO3 | Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 | cell cycle | [36] |
| Du W, 2017 | circFOXO3 | FOXO3 | Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses | cardiac senescence | [37] |
| Du W, 2017 | circFOXO3 | FOXO3 | Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity | tumor apoptosis | [38] |
| Shen Z, 2020 | circFOXO3 | FOXO3 | Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel | prostate cancer | [39] |
| Kong Z, 2020 | circFOXO3 | FOXO3 | Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p | prostate cancer | [40] |
| Zheng Q, 2016 | circHIPK3 | Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs | cell growth | [41] | |
| Li Y, 2017 | circHIPK3 | HIPK3 | CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells | bladder cancer | [42] |
| Zeng K, 2018 | circHIPK3 | HIPK3 | CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7 | colorectal cancer | [43] |
| Shan K, 2017 | circHIPK3 | HIPK3 | Circular noncoding RNA HIPK3 mediatesretinalvascular dysfunction in diabetes mellitus | diabetes mellitus | [44] |
| Chen G, 2018 | circHIPK3 | HIPK3 | circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma | hepatocellular carcinoma | [45] |
| Yang C, 2018 | circITCH | HIPK3 | Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression | bladder cancer | [46] |
| Guo W, 2017 | circITCH | ITCH | Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma | hepatocellular carcinoma | [47] |
| Wang M, 2018 | circITCH | ITCH | CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22–3p/CBL/beta-catenin pathway | thyroid cancer | [48] |
| Wang S, 2019 | circITCH | ITCH | Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway | breast cancer | [49] |
| Hu J, 2018 | circITCH | ITCH | The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling | ovarian carcinoma | [50] |
| Han D, 2017 | circMTO1 | MTO1 | Circular RNA circMTO1 Acts as the Sponge of MicroRNA-9 to Suppress Hepatocellular Carcinoma Progression | hepatocellular carcinoma | [51] |
| Li Y, 2019 | circMTO1 | MTO1 | Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition | bladder cancer | [52] |
| Ge Z, 2018 | circMTO1 | MTO1 | CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway in colorectal cancer | colorectal cancer | [53] |
| Chen M, 2019 | circMTO1 | MTO1 | circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893 | cervical cancer | [54] |
| Zhang B, 2019 | circMTO1 | MTO1 | A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma | lung adenocarcinoma | [55] |
| Tan Y, 2019 | circSMARCA5 | SMARCA5 | Circular RNA SMARCA5 is overexpressed and promotes cell proliferation, migration as well as invasion while inhibits cell apoptosis in bladder cancer | bladder cancer | [56] |
| Kong Z, 2017 | circSMARCA5 | SMARCA5 | Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer | prostate cancer | [57] |
| Tong S, 2020 | circSMARCA5 | SMARCA5 | Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer | non-small cell lung cancer | [58] |
| Liu H, 2019 | circSMARCA5 | SMARCA5 | Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767–5p | multiple myeloma | [59] |
| Miao X, 2020 | circSMARCA5 | SMARCA5 | Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39–3p and upregulating ARID4B | colorectal cancer | [60] |
| Zuo Y, 2020 | circZNF609 | ZNF609 | Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224–3p/ETV1 Signaling | lung adenocarcinoma | [61] |
| Guan C, 2021 | circZNF609 | ZNF609 | YY1 and eIF4A4 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432–5p to regulate LRRC1 | cholangiocarcinoma | [62] |
| Du S, 2021 | circZNF609 | ZNF609 | Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224–3p/PLK1 signaling | glioma | [63] |
| Wu L, 2018 | circZNF609 | ZNF609 | Circ-ZNF609 promotes migration of colorectal cancer by inhibiting Gli1 expression via microRNA-150 | colorectal cancer | [64] |
| Liu Z, 2019 | circZNF609 | ZNF609 | Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145–5p expression | gastric cancer | [65] |