Table 2. Two-Sample Mendelian Randomization Estimates for Associations Between Alcohol Consumption and 6 Cardiovascular Phenotypesa.
| Cardiovascular phenotype | Odds ratio (95% CI) | P value |
|---|---|---|
| Hypertension | 1.28 (1.18-1.39) | 1.73 × 10−9 |
| Coronary artery disease | 1.38 (1.10-1.74) | 6.00 × 10−3 |
| Myocardial infarction | 1.37 (1.05-1.78) | 2.00 × 10−2 |
| Stroke | 1.26 (1.04-1.54) | 2.10 × 10−2 |
| Heart failure | 1.39 (1.08-1.78) | 9.00 × 10−3 |
| Atrial fibrillation | 1.24 (1.08-1.44) | 3.00 × 10−3 |
a
Genetic instruments (the Alcohol Use Disorder–Restricted) were used to test for association with disease (in current drinkers) or for potential pleiotropy (in lifelong abstainers), as specified. Results are displayed for 2-sample mendelian randomization analyses using the inverse-variance weighted method, and odds ratios are reported per 1-SD increase in genetically predicted alcohol consumption. Bonferroni-corrected P < .008 was considered statistically significant.