Table 2. Cumulative Probability of at Least 1 False-Positive Recall After 10 Years of Screening.
| Age group and breast density | Cumulative probability (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| Annual screening | Biennial screening | Differences for biennial vs annual screening by modality | ||||||
| Digital breast tomosynthesis | Digital mammography | Difference | Digital breast tomosynthesis | Digital mammography | Difference | Digital breast tomosynthesis | Digital mammographya | |
| All screening mammograms | 49.6 (49.0 to 50.2) | 56.3 (56.0 to 56.7) | –6.7 (–7.4 to –6.1)a | 35.7 (34.8 to 36.6) | 38.1 (37.8 to 38.5) | –2.4 (–3.4 to –1.5)a | –13.9 (–14.9 to –12.8)a | –18.2 (–18.6 to –17.7) |
| Age, 40-49 y | 60.8 (59.4 to 62.1) | 68.0 (67.4 to 68.6) | –7.2 (–8.7 to –5.8)a | 46.1 (44.1 to 48.2) | 48.7 (47.9 to 49.4) | –2.5 (–4.7 to –0.3)a | –14.6 (–17.1 to –12.2)a | –19.4 (–20.3 to –18.4) |
| Almost entirely fatty | 31.0 (25.6 to 36.7) | 39.7 (37.5 to 41.9) | –8.7 (–14.6 to –2.6)a | 26.4 (18.5 to 34.8) | 24.5 (21.9 to 27.3) | 1.9 (–6.6 to 10.6) | –4.6 (–14.3 to 5.4) | –15.2 (–18.6 to –11.7) |
| Scattered fibroglandular densities | 51.8 (49.5 to 54.2) | 64.7 (63.7 to 65.6) | –12.8 (–15.3 to –10.3)a | 38.1 (34.6 to 41.6) | 44.6 (43.3 to 46.0) | –6.5 (–10.3 to –2.8)a | –13.7 (–18.0 to –9.4)a | –20.0 (–21.6 to –18.4) |
| Heterogeneously dense | 68.0 (66.1 to 69.8) | 74.2 (73.5 to 75.0) | –6.3 (–8.3 to –4.3)a | 51.9 (48.9 to 54.9) | 54.4 (53.3 to 55.5) | –2.5 (–5.7 to 0.7) | –16.1 (–19.6 to –12.6)a | –19.8 (–21.2 to –18.5) |
| Extremely dense | 67.3 (63.8 to 70.7) | 65.0 (63.6 to 66.4) | 2.3 (–1.4 to 6.0) | 51.2 (45.7 to 56.9) | 46.1 (44.1 to 48.0) | 5.2 (–0.6 to 11.1) | –16.0 (–22.6 to –9.5)a | –18.9 (–21.3 to –16.5) |
| Age, 50-59 y | 51.1 (50.3 to 51.9) | 57.6 (57.2 to 58.0) | –6.5 (–7.4 to –5.6)a | 34.8 (33.7 to 35.9) | 37.6 (37.2 to 38.0) | –2.8 (–3.9 to –1.6)a | –16.3 (–17.7 to –14.9)a | –20.0 (–20.6 to –19.5) |
| Almost entirely fatty | 29.1 (26.6 to 31.7) | 36.3 (35.3 to 37.2) | –7.2 (–9.8 to –4.4)a | 18.3 (15.5 to 21.3) | 22.6 (21.5 to 23.8) | –4.3 (–7.4 to –1.2)a | –10.8 (–14.6 to –6.9)a | –13.6 (–15.1 to –12.1) |
| Scattered fibroglandular densities | 46.7 (45.4 to 47.9) | 55.6 (55.1 to 56.2) | –9.0 (–10.3 to –7.6)a | 31.6 (30.0 to 33.2) | 36.7 (36.1 to 37.3) | –5.1 (–6.8 to –3.4)a | –15.1 (–17.1 to –13.1)a | –19.0 (–19.7 to –18.2) |
| Heterogeneously dense | 59.4 (58.1 to 60.6) | 64.7 (64.1 to 65.2) | –5.3 (–6.6 to –3.9)a | 41.0 (39.1 to 42.8) | 42.2 (41.6 to 42.9) | –1.3 (–3.2 to 0.7) | –18.4 (–20.7 to –16.2)a | –22.4 (–23.2 to –21.6) |
| Extremely dense | 60.4 (57.4 to 63.4) | 58.8 (57.6 to 59.9) | 1.7 (–1.6 to 4.8) | 42.2 (37.7 to 46.7) | 36.9 (35.3 to 38.4) | 5.3 (0.5 to 10.1) | –18.3 (–23.6 to –12.8)a | –21.9 (–23.8 to –20.0) |
| Age, 60-69 y | 44.0 (43.2 to 44.9) | 50.4 (50.0 to 50.8) | –6.3 (–7.3 to –5.4)a | 29.3 (28.2 to 30.4) | 31.7 (31.3 to 32.1) | –2.4 (–3.6 to –1.2)a | –14.7 (–16.1 to –13.4)a | –18.6 (–19.2 to –18.1) |
| Almost entirely fatty | 27.6 (25.3 to 30.0) | 34.1 (33.2 to 35.0) | –6.5 (–9.0 to –3.9)a | 17.2 (14.6 to 20.1) | 22.6 (21.5 to 23.6) | –5.3 (–8.2 to –2.3)a | –10.4 (–13.9 to –6.8)a | –11.5 (–12.9 to –10.1) |
| Scattered fibroglandular densities | 42.5 (41.3 to 43.7) | 50.2 (49.7 to 50.8) | –7.7 (–9.0 to –6.4)a | 28.7 (27.2 to 30.3) | 32.0 (31.4 to 32.6) | –3.3 (–4.9 to –1.6)a | –13.8 (–15.8 to –11.9)a | –18.2 (–19.0 to –17.4) |
| Heterogeneously dense | 52.9 (51.6 to 54.3) | 57.6 (57.1 to 58.2) | –4.7 (–6.2 to –3.3)a | 34.9 (33.0 to 37.0) | 35.6 (34.9 to 36.3) | –0.7 (–2.8 to 1.4) | –18.0 (–20.4 to –15.5)a | –22.0 (–22.9 to –21.1) |
| Extremely dense | 49.0 (45.3 to 52.6) | 50.2 (48.8 to 51.6) | –1.3 (–5.2 to 2.6) | 34.8 (29.2 to 40.4) | 29.3 (27.4 to 31.2) | 5.5 (–0.4 to 11.4) | –14.2 (–20.8 to –7.5)a | –20.9 (–23.3 to –18.6) |
| Age, 70-79 y | 39.8 (38.5 to 41.2) | 47.0 (46.5 to 47.5) | –7.2 (–8.6 to –5.7)a | 28.6 (26.6 to 30.7) | 29.7 (29.0 to 30.4) | –1.1 (–3.2 to 1.1) | –11.2 (–13.6 to –8.7)a | –17.3 (–18.2 to –16.4) |
| Almost entirely fatty | 26.5 (22.9 to 30.1) | 33.0 (31.8 to 34.3) | –6.5 (–10.4 to –2.7)a | 21.8 (16.7 to 26.8) | 24.2 (22.4 to 25.9) | –2.4 (–7.9 to 3.0) | –4.8 (–11.0 to 1.4) | –8.8 (–11.0 to –6.7) |
| Scattered fibroglandular densities | 39.3 (37.4 to 41.1) | 48.0 (47.3 to 48.6) | –8.7 (–10.7 to –6.8)a | 28.7 (26.0 to 31.4) | 29.9 (28.9 to 30.9) | –1.2 (–4.0 to 1.7) | –10.6 (–13.8 to –7.3)a | –18.1 (–19.3 to –16.9) |
| Heterogeneously dense | 48.3 (45.8 to 50.8) | 53.0 (52.1 to 53.9) | –4.7 (–7.3 to –2.1)a | 32.4 (28.4 to 36.4) | 33.2 (31.8 to 34.6) | –0.7 (–5.1 to 3.5) | –15.9 (–20.5 to –11.2)a | –19.8 (–21.5 to –18.2) |
| Extremely dense | 34.9 (27.1 to 42.6) | 40.2 (37.2 to 43.1) | –5.3 (–13.6 to 2.8) | 29.3 (18.0 to 40.5) | 23.3 (19.3 to 27.4) | 6.0 (–6.1 to 17.9) | –5.6 (–19.2 to 8.1) | –16.9 (–21.8 to –11.8) |
a
Statistically significant.