Table 3. Cumulative Probability of at Least 1 False-Positive Short-Interval Follow-up Recommendation After 10 Years of Screening.
| Age group and breast density | Cumulative probability (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| Annual screening | Biennial screening | Differences for biennial vs annual screening by modality | ||||||
| Digital breast tomosynthesis | Digital mammography | Difference | Digital breast tomosynthesis | Digital mammography | Difference | Digital breast tomosynthesis | Digital mammographya | |
| All screening mammograms | 16.6 (16.1 to 17.1) | 17.8 (17.4 to 18.2) | –1.1 (–1.7 to –0.6)a | 10.3 (9.8 to 10.9) | 10.5 (10.2 to 10.7) | –0.1 (–0.7 to 0.5) | –6.3 (–7.0 to –5.6)a | –7.3 (–7.7 to –6.9) |
| Age, 40-49 y | 20.7 (19.6 to 21.8) | 20.9 (20.4 to 21.5) | –0.3 (–1.4 to 0.9) | 13.1 (11.9 to 14.4) | 13.2 (12.8 to 13.7) | –0.1 (–1.4 to 1.3) | –7.5 (–9.2 to –5.9)a | –7.7 (–8.4 to –7.0) |
| Almost entirely fatty | 6.6 (4.0 to 9.6) | 11.8 (10.4 to 13.3) | –5.2 (–8.2 to –1.9)a | 6.6 (3.0 to 10.9) | 7.6 (6.1 to 9.3) | –1.0 (–5.0 to 3.5) | 0.0 (–4.7 to 4.9) | –4.2 (–6.4 to –2.0) |
| Scattered fibroglandular densities | 17.5 (15.8 to 19.2) | 18.6 (17.8 to 19.4) | –1.1 (–3.0 to 0.7) | 10.5 (8.6 to 12.6) | 11.6 (10.8 to 12.4) | –1.1 (–3.1 to 1.1) | –7.0 (–9.6 to –4.3)a | –7.0 (–8.1 to –6.0) |
| Heterogeneously dense | 23.5 (22.0 to 25.1) | 23.3 (22.6 to 24.1) | 0.2 (–1.5 to 1.9) | 14.6 (12.7 to 16.5) | 14.9 (14.2 to 15.6) | –0.4 (–2.4 to 1.7) | –8.9 (–11.4 to –6.5)a | –8.4 (–9.4 to –7.4) |
| Extremely dense | 23.2 (20.5 to 26.0) | 21.3 (20.2 to 22.5) | 1.9 (–1.0 to 4.9) | 16.5 (12.9 to 20.4) | 13.0 (11.8 to 14.3) | 3.5 (–0.3 to 7.5) | –6.7 (–11.4 to –2.1)a | –8.3 (–10.0 to –6.6) |
| Age, 50-59 y | 17.0 (16.3 to 17.7) | 18.5 (18.1 to 19.0) | –1.5 (–2.2 to –0.9)a | 10.0 (9.4 to 10.7) | 10.5 (10.2 to 10.7) | –0.4 (–1.1 to 0.3) | –7.0 (–7.9 to –6.1)a | –8.1 (–8.6 to –7.6) |
| Almost entirely fatty | 8.9 (7.3 to 10.6) | 11.6 (10.9 to 12.3) | –2.7 (–4.5 to –0.9)a | 5.3 (3.7 to 7.0) | 6.8 (6.1 to 7.5) | –1.5 (–3.2 to 0.3) | –3.6 (–5.9 to –1.2)a | –4.8 (–5.8 to –3.9) |
| Scattered fibroglandular densities | 15.9 (15.0 to 16.8) | 17.6 (17.1 to 18.1) | –1.7 (–2.7 to –0.8)a | 9.9 (8.9 to 10.9) | 10.1 (9.7 to 10.5) | –0.2 (–1.3 to 0.8) | –6.0 (–7.3 to –4.7)a | –7.5 (–8.1 to –6.9) |
| Heterogeneously dense | 19.5 (18.5 to 20.6) | 20.9 (20.4 to 21.5) | –1.4 (–2.5 to –0.3)a | 11.1 (10.0 to 12.2) | 11.8 (11.3 to 12.2) | –0.6 (–1.8 to 0.5) | –8.4 (–9.9 to –6.9)a | –9.2 (–9.9 to –8.5) |
| Extremely dense | 19.8 (17.3 to 22.3) | 19.5 (18.5 to 20.6) | 0.2 (–2.4 to 3.0) | 11.1 (8.3 to 14.2) | 10.2 (9.1 to 11.2) | 1.0 (–2.0 to 4.1) | –8.6 (–12.5 to –4.7)a | –9.4 (–10.8 to –7.9) |
| Age, 60-69 y | 14.7 (14.1 to 15.3) | 16.2 (15.8 to 16.6) | –1.5 (–2.2 to –0.9)a | 8.7 (8.0 to 9.4) | 8.8 (8.5 to 9.0) | –0.1 (–0.8 to 0.7) | –6.0 (–6.9 to –5.1)a | –7.5 (–7.9 to –7.0) |
| Almost entirely fatty | 8.9 (7.4 to 10.5) | 11.1 (10.4 to 11.8) | –2.2 (–3.9 to –0.5)a | 5.5 (4.0 to 7.2) | 6.7 (6.0 to 7.3) | –1.1 (–2.8 to 0.7) | –3.4 (–5.6 to –1.1)a | –4.4 (–5.3 to –3.5) |
| Scattered fibroglandular densities | 14.9 (14.0 to 15.7) | 16.1 (15.7 to 16.6) | –1.3 (–2.2 to –0.4)a | 9.4 (8.4 to 10.4) | 9.0 (8.6 to 9.4) | 0.4 (–0.6 to 1.5) | –5.5 (–6.8 to –4.2)a | –7.1 (–7.7 to –6.6) |
| Heterogeneously dense | 16.8 (15.8 to 17.8) | 18.6 (18.1 to 19.2) | –1.8 (–2.9 to –0.7)a | 9.2 (8.1 to 10.4) | 9.4 (9.0 to 9.9) | –0.2 (–1.5 to 1.0) | –7.6 (–9.1 to –6.1)a | –9.2 (–9.9 to –8.5) |
| Extremely dense | 14.7 (12.0 to 17.5) | 14.9 (13.7 to 16.0) | –0.1 (–3.1 to 2.9) | 6.3 (3.1 to 9.4) | 7.3 (6.2 to 8.5) | –1.0 (–4.4 to 2.3) | –8.4 (–12.6 to –4.2)a | –7.5 (–9.1 to –5.9) |
| Age, 70-79 y | 13.3 (12.3 to 14.3) | 14.2 (13.8 to 14.6) | –0.9 (–2.0 to 0.2) | 8.4 (7.2 to 9.7) | 7.8 (7.4 to 8.3) | 0.6 (–0.7 to 2.0) | –4.9 (–6.5 to –3.3)a | –6.4 (–7.0 to –5.8) |
| Almost entirely fatty | 6.5 (4.5 to 8.8) | 10.3 (9.4 to 11.2) | –3.8 (–6.0 to –1.4)a | 7.5 (4.3 to 11.0) | 7.2 (6.1 to 8.3) | 0.3 (–3.0 to 4.0) | 1.0 (–2.9 to 5.0) | –3.1 (–4.5 to –1.7) |
| Scattered fibroglandular densities | 14.4 (13.0 to 15.8) | 14.3 (13.8 to 14.9) | 0.1 (–1.4 to 1.6) | 9.0 (7.3 to 10.8) | 8.2 (7.6 to 8.8) | 0.8 (–1.0 to 2.7) | –5.4 (–7.6 to –3.1)a | –6.1 (–6.9 to –5.3) |
| Heterogeneously dense | 15.1 (13.1 to 17.1) | 16.4 (15.7 to 17.2) | –1.4 (–3.4 to 0.8) | 8.3 (6.2 to 10.6) | 7.7 (6.9 to 8.6) | 0.6 (–1.8 to 3.0) | –6.7 (–9.7 to –3.8)a | –8.7 (–9.8 to –7.5) |
| Extremely dense | 9.7 (5.2 to 14.9) | 9.3 (7.4 to 11.2) | 0.4 (–4.4 to 6.0) | 3.6 (0.4 to 10.0) | 5.0 (3.0 to 7.3) | –1.3 (–5.7 to 5.3) | –6.0 (–12.7 to 1.7) | –4.3 (–7.0 to –1.4) |
a
Statistically significant.